Real-Time PCR Kit - Cardiovascular Test Kits
Detect Factor II, Factor V, and other cardiovascular diseases with real-time PCR kits.
In individuals already ill (with unclear symptoms), modern genetic diagnostic methods allow for a simple and reliable differential diagnosis.
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| Angiotensin Converting Enzyme (MutaREAL® ACE) | Angiotensin-converting enzyme (ACE) is an important regulator in the renin-angiotensin-aldosterone system (RAAS). It converts angiotensin I into the physiologically active form angiotensin II, which exerts its vasoconstrictive effect on target organs (heart, kidneys, blood vessel walls). | Sample volume: 200 µl Sample matrix: DNA (e.g. from whole blood, cheek swab) Method: real time PCR (capillary system) | 96 tests |
| Factor II (Muta PLATE®/ REAL® Factor II (Prothrombin) | In contrast to disorders of the blood coagulation system that interrupt the coagulation process and cause hemophilia, thrombophilias are pathological overfunctions of coagulation-promoting proteins or inactivators of anticoagulation, as in the case of prothrombin mutation (= factor II G20210A), APC resistance due to proaccelerin mutation (factor V Leiden), or antiphospholipid syndrome/hyperhomocysteinemia. | Sample Volume: 200 µl Sample matrix: DNA (e.g. from whole blood, cheek swab) Method: real time PCR (open system) | 96 tests |
| Factor V (MutaPLATE®/ REAL® Factor V) | Coagulation factor V (F5) is converted into its active form (factor Va) by thrombin (F2), which is an essential protein in blood coagulation and is itself a co-factor for the conversion of prothrombin to thrombin. | Sample volume: 200 µl Sample matrix: DNA (e.g. from whole blood, cheek swab) Method: real time PCR (offene Systeme) | 96 tests |
| Methylentetrahydrofolatreduktase (MutaPLATE® MTHFR) | Homocysteinemia resulting from reduced MTHFR activity often leads to endothelial damage in blood vessels. These microlesions promote deposits, which can lead to vascular occlusion. | Sample volume: 200 µl Sample matrix: DNA (e.g. cheek swab from biological materials) Method: real time PCR (open system) | 96 tests |
| Plasminogen-Aktivator-Inhibitor Typ 1 (MutaREAL® PAI-1) | Plasminogen activator inhibitor type 1 (PAI-1) inhibits proteins responsible for thrombus resorption (plasminogen activators and urokinase). Therefore, elevated PAI-1 levels limit fibrinolysis and thus represent a risk factor for venous and arterial thrombosis. An increased tendency for metastasis of various cancers and correlations between insulin resistance and the occurrence of myocardial infarctions have also been observed in association with the PAI-1 genotype. | Sample matrix: DNA (e.g. from whole blood, cheek swab) Method: real time PCR (capillary system) | 96 tests |